Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

OBJECTIVE: To determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis. APPROACH AND RESULTS: Using a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the Ldlr(–/...

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Detalles Bibliográficos
Autores principales: Yap, Jonathan, McCurdy, Sara, Alcala, Martin, Irei, Jason, Garo, Jan, Regan, Whitney, Lee, Bog-Hieu, Kitamoto, Shiro, Boisvert, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324766/
https://www.ncbi.nlm.nih.gov/pubmed/32655419
http://dx.doi.org/10.3389/fphys.2020.00714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324766/
https://www.ncbi.nlm.nih.gov/pubmed/32655419
http://dx.doi.org/10.3389/fphys.2020.00714

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