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Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial
BACKGROUND: Sickle cell disease (SCD) is a genetic disorder which causes dysfunctional red blood cells (RBC) and is thought to increase requirements for folate, an essential B vitamin, due to increased RBC production and turnover in the disease. High-dose supplementation with 1–5 mg/d folic acid, sy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325072/ https://www.ncbi.nlm.nih.gov/pubmed/32600389 http://dx.doi.org/10.1186/s13063-020-04540-7 |