Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling

Antiretroviral therapy during pregnancy reduces the risk of vertical HIV‐1 transmission. However, drug dosing is challenging as pharmacokinetics (PK) may be altered during pregnancy. We combined a pregnancy physiologically‐based pharmacokinetic (PBPK) modeling approach with data on placental drug tr...

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Detalles Bibliográficos
Autores principales: Freriksen, Jolien J.M., Schalkwijk, Stein, Colbers, Angela P., Abduljalil, Khaled, Russel, Frans G.M., Burger, David M., Greupink, Rick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325314/
https://www.ncbi.nlm.nih.gov/pubmed/31868223
http://dx.doi.org/10.1002/cpt.1748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325314/
https://www.ncbi.nlm.nih.gov/pubmed/31868223
http://dx.doi.org/10.1002/cpt.1748

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