Gene–Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is caused by mutations within the Mediterranean fever (MEFV) gene. Disease severity depends on genotype and gene dose with most serious clinical courses observed in patients with M694V homozygosity. Neutrophils are thought to play an important role in the initiatio...

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Detalles Bibliográficos
Autores principales: Stoler, Iris, Freytag, Judith, Orak, Banu, Unterwalder, Nadine, Henning, Stephan, Heim, Katrin, von Bernuth, Horst, Krüger, Renate, Winkler, Stefan, Eschenhagen, Patience, Seipelt, Eva, Mall, Marcus A., Foell, Dirk, Kessel, Christoph, Wittkowski, Helmut, Kallinich, Tilmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325897/
https://www.ncbi.nlm.nih.gov/pubmed/32655537
http://dx.doi.org/10.3389/fimmu.2020.00716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325897/
https://www.ncbi.nlm.nih.gov/pubmed/32655537
http://dx.doi.org/10.3389/fimmu.2020.00716

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