Induction of in vitro Metabolic Zonation in Primary Hepatocytes Requires Both Near-Physiological Oxygen Concentration and Flux

Pre-clinical drug screening is an important step in assessing the metabolic effects and hepatic toxicity of new pharmaceutical compounds. However, due to the complexity of the liver microarchitecture, simplified in vitro models do not adequately reflect in vivo situations. Especially spatial heterog...

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Detalles Bibliográficos
Autores principales: Scheidecker, Benedikt, Shinohara, Marie, Sugimoto, Masahiro, Danoy, Mathieu, Nishikawa, Masaki, Sakai, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325921/
https://www.ncbi.nlm.nih.gov/pubmed/32656187
http://dx.doi.org/10.3389/fbioe.2020.00524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325921/
https://www.ncbi.nlm.nih.gov/pubmed/32656187
http://dx.doi.org/10.3389/fbioe.2020.00524

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