Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in a physiological setting by designing novel to...

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Detalles Bibliográficos
Autores principales: Zhu, Rong, Sandtner, Walter, Ahiable, Joan E. A., Newman, Amy Hauck, Freissmuth, Michael, Sitte, Harald H., Hinterdorfer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325972/
https://www.ncbi.nlm.nih.gov/pubmed/32656227
http://dx.doi.org/10.3389/fmolb.2020.00099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325972/
https://www.ncbi.nlm.nih.gov/pubmed/32656227
http://dx.doi.org/10.3389/fmolb.2020.00099

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