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Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders
Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their applicati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326106/ https://www.ncbi.nlm.nih.gov/pubmed/32670022 http://dx.doi.org/10.3389/fncel.2020.00133 |
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author | Chen, Augustin Guo, Zhenming Fang, Lipao Bian, Shan |
author_facet | Chen, Augustin Guo, Zhenming Fang, Lipao Bian, Shan |
author_sort | Chen, Augustin |
collection | PubMed |
description | Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their application in modeling intricate biology, such as the interaction between different brain regions. To overcome these drawbacks, brain organoids have been pre-patterned into specific brain regions and fused to form an assembloid that represents reproducible models recapitulating more complex biological processes of human brain development and neurological diseases. This approach has been applied to model interneuron migration, neuronal projections, tumor invasion, oligodendrogenesis, forebrain axis establishment, and brain vascularization. In this review article, we will summarize the usage of this technology to understand the fundamental biology underpinning human brain development and disorders. |
format | Online Article Text |
id | pubmed-7326106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73261062020-07-14 Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders Chen, Augustin Guo, Zhenming Fang, Lipao Bian, Shan Front Cell Neurosci Cellular Neuroscience Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their application in modeling intricate biology, such as the interaction between different brain regions. To overcome these drawbacks, brain organoids have been pre-patterned into specific brain regions and fused to form an assembloid that represents reproducible models recapitulating more complex biological processes of human brain development and neurological diseases. This approach has been applied to model interneuron migration, neuronal projections, tumor invasion, oligodendrogenesis, forebrain axis establishment, and brain vascularization. In this review article, we will summarize the usage of this technology to understand the fundamental biology underpinning human brain development and disorders. Frontiers Media S.A. 2020-05-15 /pmc/articles/PMC7326106/ /pubmed/32670022 http://dx.doi.org/10.3389/fncel.2020.00133 Text en Copyright © 2020 Chen, Guo, Fang and Bian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Chen, Augustin Guo, Zhenming Fang, Lipao Bian, Shan Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title_full | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title_fullStr | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title_full_unstemmed | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title_short | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
title_sort | application of fused organoid models to study human brain development and neural disorders |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326106/ https://www.ncbi.nlm.nih.gov/pubmed/32670022 http://dx.doi.org/10.3389/fncel.2020.00133 |
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