Cargando…
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
The tumor microenvironment (TME) consists of different cell types, including tumor-associated macrophages (TAMs) and tumor-associated fibroblasts (TAFs). How these cells interact and contribute to lung carcinogenesis remains elusive. Using (G12D)KRAS- and (V600E)BRAF-driven mouse lung models, we ide...
Autores principales: | Kamata, Tamihiro, So, Tsz Y., Ahmed, Qasim, Giblett, Susan, Patel, Bipin, Luo, Jinli, Reddel, Roger, Pritchard, Catrin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326292/ https://www.ncbi.nlm.nih.gov/pubmed/32579928 http://dx.doi.org/10.1016/j.celrep.2020.107802 |
Ejemplares similares
-
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours
por: Kamata, Tamihiro, et al.
Publicado: (2015) -
Statins mediate anti- and pro-tumourigenic functions by remodelling the tumour microenvironment
por: Kamata, Tamihiro, et al.
Publicado: (2022) -
Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma
por: Al Dujaily, Esraa, et al.
Publicado: (2019) -
Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy
por: Harber, James, et al.
Publicado: (2021) -
Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor
por: Hernandez, Maria Aguilar, et al.
Publicado: (2016)