Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deleti...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamming, Renee J., Dumeaux, Vanessa, Jiang, Yan, Shafiq, Sarfraz, Langlois, Luana, Ellegood, Jacob, Qiu, Lily R., Lerch, Jason P., Bérubé, Nathalie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326465/
https://www.ncbi.nlm.nih.gov/pubmed/32610139
http://dx.doi.org/10.1016/j.celrep.2020.107838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326465/
https://www.ncbi.nlm.nih.gov/pubmed/32610139
http://dx.doi.org/10.1016/j.celrep.2020.107838

Ejemplares similares