Angiotensin-(1–7) Attenuates Protein O-GlcNAcylation in the Retina by EPAC/Rap1-Dependent Inhibition of O-GlcNAc Transferase

PURPOSE: O-GlcNAcylation of cellular proteins contributes to the pathophysiology of diabetes and evidence supports a role for augmented O-GlcNAcylation in diabetic retinopathy. The aim of this study was to investigate the impact of the renin-angiotensin system on retinal protein O-GlcNAcylation. MET...

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Detalles Bibliográficos
Autores principales: Dierschke, Sadie K., Toro, Allyson L., Barber, Alistair J., Arnold, Amy C., Dennis, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326568/
https://www.ncbi.nlm.nih.gov/pubmed/32068794
http://dx.doi.org/10.1167/iovs.61.2.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326568/
https://www.ncbi.nlm.nih.gov/pubmed/32068794
http://dx.doi.org/10.1167/iovs.61.2.24

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