N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats

BACKGROUND: Neonatal abstinence syndrome (NAS) is a significant problem. Opioid withdrawal induces oxidative stress and disrupts glutamate and glutathione homeostasis. We hypothesized that N-acetylcysteine (NAC) administered during acute opioid withdrawal in neonatal rats would decrease withdrawal b...

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Detalles Bibliográficos
Autores principales: Ward, Price, Moss, Hunter G., Brown, Truman R., Kalivas, Peter, Jenkins, Dorothea D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Basic Science Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326708/
https://www.ncbi.nlm.nih.gov/pubmed/31935745
http://dx.doi.org/10.1038/s41390-019-0728-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326708/
https://www.ncbi.nlm.nih.gov/pubmed/31935745
http://dx.doi.org/10.1038/s41390-019-0728-6

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