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Systematic engineering of branch chain amino acid supply modules for the enhanced production of bacitracin from Bacillus licheniformis
Bacitracin is a broad-spectrum cyclic peptide antibiotic mainly produced by Bacillus, precursor amino acid supply served as the critical role during its synthesis. In this study, we systematically engineered branch-chain amino acid (BCAA) supply modules for bacitracin production. Firstly, we demonst...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326738/ https://www.ncbi.nlm.nih.gov/pubmed/32637317 http://dx.doi.org/10.1016/j.mec.2020.e00136 |