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Off-Peak 594-nm Light Surpasses On-Peak 532-nm Light in Silencing Distant ArchT-Expressing Neurons In Vivo

For large brain volume manipulations using optogenetics, both effective opsin excitation and efficient light delivery with minimal light absorption are required to minimize the illuminating light intensity and concomitant off-target effects. ArchT, a widely used potent inhibitory opsin, is commonly...

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Detalles Bibliográficos
Autores principales: Setsuie, Rieko, Tamura, Keita, Miyamoto, Kentaro, Watanabe, Takamitsu, Takeda, Masaki, Miyashita, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326739/
https://www.ncbi.nlm.nih.gov/pubmed/32599561
http://dx.doi.org/10.1016/j.isci.2020.101276