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Tet3 regulates cellular identity and DNA methylation in neural progenitor cells
TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a process thought to be intermediary in an active DNA demethylation mechanism. Notably, 5hmC is highly abundant in the brain and in neuronal cells. Here, we interrogated the function of Tet3 in neural precursor cells (NP...
Autores principales: | Santiago, Mafalda, Antunes, Claudia, Guedes, Marta, Iacovino, Michelina, Kyba, Michael, Reik, Wolf, Sousa, Nuno, Pinto, Luísa, Branco, Miguel R., Marques, C. Joana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326798/ https://www.ncbi.nlm.nih.gov/pubmed/31646359 http://dx.doi.org/10.1007/s00018-019-03335-7 |
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