Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet

Mitochondrial lysine acetylation regulates several metabolic pathways in cardiac cells. The current study investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metabolic proteins in response to a high fat diet (HFD). GCN5L1 cardiac-specific knockout (cKO) mice showe...

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Detalles Bibliográficos
Autores principales: Thapa, Dharendra, Manning, Janet R., Stoner, Michael W., Zhang, Manling, Xie, Bingxian, Scott, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326908/
https://www.ncbi.nlm.nih.gov/pubmed/32606301
http://dx.doi.org/10.1038/s41598-020-67812-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326908/
https://www.ncbi.nlm.nih.gov/pubmed/32606301
http://dx.doi.org/10.1038/s41598-020-67812-x

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