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Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet
Mitochondrial lysine acetylation regulates several metabolic pathways in cardiac cells. The current study investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metabolic proteins in response to a high fat diet (HFD). GCN5L1 cardiac-specific knockout (cKO) mice showe...
Autores principales: | Thapa, Dharendra, Manning, Janet R., Stoner, Michael W., Zhang, Manling, Xie, Bingxian, Scott, Iain |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326908/ https://www.ncbi.nlm.nih.gov/pubmed/32606301 http://dx.doi.org/10.1038/s41598-020-67812-x |
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