Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

HIV-1 protease inhibitors (PIs), such as darunavir (DRV), are the key component of antiretroviral therapy. However, HIV-1 often acquires resistance to PIs. Here, seven novel PIs were synthesized, by introducing single atom changes such as an exchange of a sulfur to an oxygen, scission of a single bo...

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Detalles Bibliográficos
Autores principales: Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326966/
https://www.ncbi.nlm.nih.gov/pubmed/32606378
http://dx.doi.org/10.1038/s41598-020-65993-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326966/
https://www.ncbi.nlm.nih.gov/pubmed/32606378
http://dx.doi.org/10.1038/s41598-020-65993-z

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