Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance

Leptin resistance is an important mechanism underlying the development and maintenance of obesity and is thus regarded as a promising target of obesity treatment. Plasminogen activator inhibitor 1 (PAI-1), a physiological inhibitor of tissue-type and urokinase-type plasminogen activators, is produce...

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Detalles Bibliográficos
Autores principales: Hosaka, Shinichiro, Yamada, Tetsuya, Takahashi, Kei, Dan, Takashi, Kaneko, Keizo, Kodama, Shinjiro, Asai, Yoichiro, Munakata, Yuichiro, Endo, Akira, Sugawara, Hiroto, Kawana, Yohei, Yamamoto, Junpei, Izumi, Tomohito, Sawada, Shojiro, Imai, Junta, Miyata, Toshio, Katagiri, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327106/
https://www.ncbi.nlm.nih.gov/pubmed/32670063
http://dx.doi.org/10.3389/fphar.2020.00943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327106/
https://www.ncbi.nlm.nih.gov/pubmed/32670063
http://dx.doi.org/10.3389/fphar.2020.00943

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