Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial

Antibodies (Abs) specific for CD4-induced envelope (Env) epitopes within constant region 1 and 2 (C1/C2) were induced in the RV144 vaccine trial, where antibody-dependent cellular cytotoxicity (ADCC) correlated with reduced risk of HIV-1 infection. We combined X-ray crystallography and fluorescence...

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Detalles Bibliográficos
Autores principales: Tolbert, William D., Van, Verna, Sherburn, Rebekah, Tuyishime, Marina, Yan, Fang, Nguyen, Dung N., Stanfield-Oakley, Sherry, Easterhoff, David, Bonsignori, Mattia, Haynes, Barton F., Moody, M. Anthony, Ray, Krishanu, Ferrari, Guido, Lewis, George K., Pazgier, Marzena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327165/
https://www.ncbi.nlm.nih.gov/pubmed/32605979
http://dx.doi.org/10.1128/mBio.00208-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327165/
https://www.ncbi.nlm.nih.gov/pubmed/32605979
http://dx.doi.org/10.1128/mBio.00208-20

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