Cargando…

Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial

Antibodies (Abs) specific for CD4-induced envelope (Env) epitopes within constant region 1 and 2 (C1/C2) were induced in the RV144 vaccine trial, where antibody-dependent cellular cytotoxicity (ADCC) correlated with reduced risk of HIV-1 infection. We combined X-ray crystallography and fluorescence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tolbert, William D., Van, Verna, Sherburn, Rebekah, Tuyishime, Marina, Yan, Fang, Nguyen, Dung N., Stanfield-Oakley, Sherry, Easterhoff, David, Bonsignori, Mattia, Haynes, Barton F., Moody, M. Anthony, Ray, Krishanu, Ferrari, Guido, Lewis, George K., Pazgier, Marzena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327165/ https://www.ncbi.nlm.nih.gov/pubmed/32605979 http://dx.doi.org/10.1128/mBio.00208-20

Ejemplares similares

Erratum for Tolbert et al., “Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial”
por: Tolbert, William D., et al.
Publicado: (2021)

Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions
por: Sherburn, Rebekah, et al.
Publicado: (2021)

Structural Basis for Epitopes in the gp120 Cluster A Region that Invokes Potent Effector Cell Activity
por: Tolbert, William D., et al.
Publicado: (2019)

Effects of gp120 Inner Domain (ID2) Immunogen Doses on Elicitation of Anti-HIV-1 Functional Fc-Effector Response to C1/C2 (Cluster A) Epitopes in Mice
por: Sherburn, Rebekah, et al.
Publicado: (2020)

Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site
por: Tolbert, William D., et al.
Publicado: (2020)

Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques
por: Tolbert, William D., et al.
Publicado: (2022)

Induction of Fc-Mediated Effector Functions Against a Stabilized Inner Domain of HIV-1 gp120 Designed to Selectively Harbor the A32 Epitope Region
por: Visciano, Maria L., et al.
Publicado: (2019)

Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity [ADCC] Responses
por: Pollara, Justin, et al.
Publicado: (2013)

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s
por: Tolbert, William D., et al.
Publicado: (2022)

Additional boosting to the RV144 vaccine regimen increased Fc-mediated effector function magnitude but not durability
por: Shubin, Zhanna, et al.
Publicado: (2023)

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
por: Chen, Yaozong, et al.
Publicado: (2021)

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
por: Chen, Yaozong, et al.
Publicado: (2022)

Evaluation of Rv0220, Rv2958c, Rv2994 and Rv3347c of Mycobacterium tuberculosis for serodiagnosis of tuberculosis
por: You, Xiaolong, et al.
Publicado: (2017)

Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
por: Richard, Jonathan, et al.
Publicado: (2021)

Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
por: Gomez, Andromeda, et al.
Publicado: (2016)

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC
por: Ding, Shilei, et al.
Publicado: (2023)

Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer
por: Tolbert, William D., et al.
Publicado: (2021)

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates
por: Shahi, Fatemeh, et al.
Publicado: (2021)

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC
por: Ding, Shilei, et al.
Publicado: (2023)

Humoral Responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR Regulon-Encoded Proteins of Mycobacterium tuberculosis in Individuals with Latent Tuberculosis Infection
por: Kimuda, Simon G., et al.
Publicado: (2017)

Evaluation of Triple Fragment Vaccine HSPX (Rv2031c) + PPE44 (Rv2770c) + Mouse IgG(1 )(Fcγ2a) with Auxiliary Adjuncts IL-22 in Comparison with BCG Vaccine
por: Valizadeh, Azar, et al.
Publicado: (2022)

Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c Proteins Participate in the Suppression of Macrophage Apoptosis
por: Danelishvili, Lia, et al.
Publicado: (2010)

Antigens Rv0310c and Rv1255c are promising novel biomarkers for the diagnosis of Mycobacterium tuberculosis infection
por: Luo, Liulin, et al.
Publicado: (2017)

Rv2031c of Mycobacterium tuberculosis: a master regulator of Rv2028–Rv2031 (HspX) operon
por: Mushtaq, Khurram, et al.
Publicado: (2015)

Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies
por: Álvarez-Almazán, Samuel, et al.
Publicado: (2023)

Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv
por: Målen, Hiwa, et al.
Publicado: (2010)

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions
por: Pierre, Camille N., et al.
Publicado: (2023)

V1/V2-directed antibodies elicited in RV144 vaccinees bind to a structurally polymorphic site
por: McLellan, JS, et al.
Publicado: (2012)

Use of Rv0222-Rv2657c-Rv1509 Fusion Protein to Improve the Accuracy of an Antibody ELISA for Extra-Pulmonary Tuberculosis in Humans
por: Chen, Yingyu, et al.
Publicado: (2021)

Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair
por: Tandon, Himani, et al.
Publicado: (2019)

Non-observation of $^{12}C$ cluster decay of $^{114}Ba$
por: Guglielmetti, A, et al.
Publicado: (1997)

Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c
por: Tükenmez, Hasan, et al.
Publicado: (2021)

Role of intragenic binding of cAMP responsive protein (CRP) in regulation of the succinate dehydrogenase genes Rv0249c-Rv0247c in TB complex mycobacteria
por: Knapp, Gwendowlyn S., et al.
Publicado: (2015)

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils
por: Dziadek, Bozena, et al.
Publicado: (2016)

Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies
por: Mielke, Dieter, et al.
Publicado: (2022)

MiaA (Rv2727c) mediated tRNA isopentenylation of Mycobacterium tuberculosis H37Rv
por: Soman, Smitha, et al.
Publicado: (2022)

Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure
por: Ray, Krishanu, et al.
Publicado: (2019)

Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy
por: Agrawal, Parul, et al.
Publicado: (2019)

P04-01. Simultaneous enumeration of HIV-1 gp41 Env-specific IgG and IgM antibody-secreting cells with a multiplex B-cell fluorospot assay
por: Bonsignori, M, et al.
Publicado: (2009)

HIV-1 Vpu restricts Fc-mediated effector functions in vivo
por: Prévost, Jérémie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kdvj10ekeat1lsjopd0a545j2b