Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure–function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly s...

Descripción completa

Detalles Bibliográficos
Autores principales: Babkova, Petra, Dunajova, Zuzana, Chaloupkova, Radka, Damborsky, Jiri, Bednar, David, Marek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327271/
https://www.ncbi.nlm.nih.gov/pubmed/32637047
http://dx.doi.org/10.1016/j.csbj.2020.06.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327271/
https://www.ncbi.nlm.nih.gov/pubmed/32637047
http://dx.doi.org/10.1016/j.csbj.2020.06.021

Ejemplares similares