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Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

Ancestral sequence reconstruction is a powerful method for inferring ancestors of modern enzymes and for studying structure–function relationships of enzymes. We have previously applied this approach to haloalkane dehalogenases (HLDs) from the subfamily HLD-II and obtained thermodynamically highly s...

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Detalles Bibliográficos
Autores principales:	Babkova, Petra, Dunajova, Zuzana, Chaloupkova, Radka, Damborsky, Jiri, Bednar, David, Marek, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327271/ https://www.ncbi.nlm.nih.gov/pubmed/32637047 http://dx.doi.org/10.1016/j.csbj.2020.06.021

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