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Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats

BACKGROUND: Urinary concentration impairment is a major feature of cyclosporine nephrotoxicity. METHODS: We explored two possible mechanisms that may underlie cyclosporine-induced polyuria; water, and/or osmotic diuresis. Cyclosporine was subcutaneously injected to normal salt-fed Sprague-Dawley rat...

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Detalles Bibliográficos
Autores principales: Lee, Jun Han, Kim, Su A, Jo, Chor Ho, Lee, Chang Hwa, Kim, Gheun-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Electrolyte Metabolism 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327388/
https://www.ncbi.nlm.nih.gov/pubmed/32655650
http://dx.doi.org/10.5049/EBP.2020.18.1.1