Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

In the outer membrane of gram‐negative bacteria, O‐antigen segments of lipopolysaccharide (LPS) form a chemomechanical barrier, whereas lipid A moieties anchor LPS molecules. Upon infection, human guanylate binding protein‐1 (hGBP1) colocalizes with intracellular gram‐negative bacterial pathogens, f...

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Detalles Bibliográficos
Autores principales: Kutsch, Miriam, Sistemich, Linda, Lesser, Cammie F, Goldberg, Marcia B, Herrmann, Christian, Coers, Jörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327485/
https://www.ncbi.nlm.nih.gov/pubmed/32510692
http://dx.doi.org/10.15252/embj.2020104926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327485/
https://www.ncbi.nlm.nih.gov/pubmed/32510692
http://dx.doi.org/10.15252/embj.2020104926

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