The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

The accumulation and prion‐like propagation of α‐synuclein and other amyloidogenic proteins are associated with devastating neurodegenerative diseases. Metazoan heat shock protein HSP70 and its co‐chaperones DNAJB1 and HSP110 constitute a disaggregation machinery that is able to disassemble α‐synucl...

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Detalles Bibliográficos
Autores principales: Tittelmeier, Jessica, Sandhof, Carl Alexander, Ries, Heidrun Maja, Druffel‐Augustin, Silke, Mogk, Axel, Bukau, Bernd, Nussbaum‐Krammer, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327497/
https://www.ncbi.nlm.nih.gov/pubmed/32449565
http://dx.doi.org/10.15252/embj.2019103954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327497/
https://www.ncbi.nlm.nih.gov/pubmed/32449565
http://dx.doi.org/10.15252/embj.2019103954

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