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Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat

Synthetic glucocorticoids are widely prescribed for the treatment of numerous inflammatory and autoimmune diseases and they can also affect the way the adrenal gland produces endogenous glucocorticoids. Indeed, patients undergoing synthetic glucocorticoid treatment can develop adrenal insufficiency,...

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Detalles Bibliográficos
Autores principales: Spiga, Francesca, Zhao, Zidong, Lightman, Stafford L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327516/
https://www.ncbi.nlm.nih.gov/pubmed/32156515
http://dx.doi.org/10.1016/j.bbi.2020.03.001