Cargando…

Transforming activities of the NUP98-KMT2A fusion gene associated with myelodysplasia and acute myeloid leukemia

Inv(11)(p15q23), found in myelodysplastic syndromes and acute myeloid leukemia, leads to expression of a fusion protein consisting of the N-terminal of nucleoporin 98 (NUP98) and the majority of the lysine methyltransferase 2A (KMT2A). To explore the transforming potential of this fusion we establis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fisher, James N., Thanasopoulou, Angeliki, Juge, Sabine, Tzankov, Alexandar, Bagger, Frederik O., Mendez, Max A., Peters, Antoine H.F.M., Schwaller, Juerg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327646/ https://www.ncbi.nlm.nih.gov/pubmed/31558671 http://dx.doi.org/10.3324/haematol.2019.219188

Ejemplares similares

S116: CELLULAR AND MOLECULAR MECHANISMS OF EVI1-EXPRESSING MLL-REARRANGED ACUTE MYELOID LEUKEMIA
por: Châtel-Soulet, Hugues-Etienne, et al.
Publicado: (2022)

Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype
por: Fahrenkrog, Birthe, et al.
Publicado: (2016)

A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia
por: Stavropoulou, Vaia, et al.
Publicado: (2018)

Loss of CCDC6 Affects Cell Cycle through Impaired Intra-S-Phase Checkpoint Control
por: Thanasopoulou, Angeliki, et al.
Publicado: (2012)

Thymic precursor cells generate acute myeloid leukemia in NUP98-PHF23/NUP98-HOXD13 double transgenic mice
por: Kundu, Subhadip, et al.
Publicado: (2019)

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
por: Leonards, Katharina, et al.
Publicado: (2020)

Uncleavable Nup98–Nup96 is functional in the fission yeast Schizosaccharomyces pombe
por: Asakawa, Haruhiko, et al.
Publicado: (2015)

Identification of GSX2 and AF10 as NUP98 partner genes in myeloid malignancies
por: Soler, G, et al.
Publicado: (2013)

The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia
por: Rio-Machin, A, et al.
Publicado: (2017)

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia
por: Mohanty, Sagarajit, et al.
Publicado: (2020)

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia
por: Bertrums, Eline J. M., et al.
Publicado: (2023)

Dynamic Association of NUP98 with the Human Genome
por: Liang, Yun, et al.
Publicado: (2013)

Nup98-Homeodomain Fusions Interact with Endogenous Nup98 during Interphase and Localize to Kinetochores and Chromosome Arms during Mitosis
por: Xu, Songli, et al.
Publicado: (2010)

The clinical and biological characteristics of NUP98-KDM5A pediatric acute myeloid leukemia
por: Noort, Sanne, et al.
Publicado: (2020)

NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia
por: Matsukawa, Toshihiro, et al.
Publicado: (2023)

SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation
por: Jevtic, Zivojin, et al.
Publicado: (2022)

Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98
por: Diez, Lisa, et al.
Publicado: (2022)

Nup98-dependent transcriptional memory is established independently of transcription
por: Pascual-Garcia, Pau, et al.
Publicado: (2022)

Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2
por: Di Giacomo, Danika, et al.
Publicado: (2014)

NUP-98 Rearrangements Led to the Identification of Candidate Biomarkers for Primary Induction Failure in Pediatric Acute Myeloid Leukemia
por: Barresi, Vincenza, et al.
Publicado: (2021)

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication
por: Di Nunzio, Francesca, et al.
Publicado: (2013)

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53
por: Piqué-Borràs, Maria-Riera, et al.
Publicado: (2023)

Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
por: Chandra, Bappaditya, et al.
Publicado: (2022)

Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation
por: Hussey, Damian J, et al.
Publicado: (2001)

Novel NUP98::ASH1L Gene Fusion in Acute Myeloid Leukemia Detected by Optical Genome Mapping
por: Tembrink, Marco, et al.
Publicado: (2023)

TP53-Mutated Myelodysplasia and Acute Myeloid Leukemia
por: Testa, Ugo, et al.
Publicado: (2023)

Tumor Microenvironment in Acute Myeloid Leukemia: Adjusting Niches
por: Menter, Thomas, et al.
Publicado: (2022)

Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach
por: Mendes, Adélia, et al.
Publicado: (2020)

Identification of the NUP98-PHF23 fusion gene in pediatric cytogenetically normal acute myeloid leukemia by whole-transcriptome sequencing
por: Togni, Marco, et al.
Publicado: (2015)

Long‐term molecular remission in a patient with acute myeloid leukemia harboring a new NUP98‐LEDGF rearrangement
por: Gallego Hernanz, Maria Pilar, et al.
Publicado: (2019)

Acute Myeloid Leukemia with NUP98-RARG Gene Fusion Similar to Acute Promyelocytic Leukemia: Case Report and Literature Review
por: Tao, Shandong, et al.
Publicado: (2020)

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression
por: Sloma, Ivan, et al.
Publicado: (2020)

A novel NUP98-JADE2 fusion in a patient with acute myeloid leukemia resembling acute promyelocytic leukemia
por: Cheng, Chi-Keung, et al.
Publicado: (2022)

First case report of a NUP98-PMX1 rearrangement in de novo acute myeloid leukemia and literature review
por: Fu, Weijia, et al.
Publicado: (2021)

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
por: Zhang, Yi, et al.
Publicado: (2020)

A simple thermodynamic description of phase separation of Nup98 FG domains
por: Ng, Sheung Chun, et al.
Publicado: (2022)

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML
por: Rasouli, Milad, et al.
Publicado: (2023)

Acute myeloid leukemia with myelodysplasia-related changes and basophilic differentiation
por: Rieu, Jean-Baptiste, et al.
Publicado: (2020)

A Conserved Biogenesis Pathway for Nucleoporins: Proteolytic Processing of a 186-Kilodalton Precursor Generates Nup98 and the Novel Nucleoporin, Nup96
por: Fontoura, Beatriz M.A., et al.
Publicado: (1999)

The Vertebrate GLFG Nucleoporin, Nup98, Is an Essential Component of Multiple RNA Export Pathways
por: Powers, Maureen A., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_chp9r0pr0l96a73cjiogmrg3h7