CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c‐Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma

BACKGROUND: Calpain 1 (CAPN1) has been found to be a promoter of cancer progression. PTPN1 as a physiological target molecule of CAPN1 plays a dephosphorylated role on multiple receptor tyrosine kinases. This study aimed to reveal the effects of CAPN1/PTPN1 on malignant phenotype and EGFR‐TKI resist...

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Detalles Bibliográficos
Autores principales: Chen, Yichuan, Tang, Jingqun, Lu, Ting, Liu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327690/
https://www.ncbi.nlm.nih.gov/pubmed/32395869
http://dx.doi.org/10.1111/1759-7714.13465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327690/
https://www.ncbi.nlm.nih.gov/pubmed/32395869
http://dx.doi.org/10.1111/1759-7714.13465

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