Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases

Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds, from new pharmaceuticals to high value commodity and specialty chemicals. Their colinear biosynthetic logic has been viewed as a promising pl...

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Detalles Bibliográficos
Autores principales: Drufva, Erin E., Hix, Elijah G., Bailey, Constance B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327777/
https://www.ncbi.nlm.nih.gov/pubmed/32637664
http://dx.doi.org/10.1016/j.synbio.2020.04.001