Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro

BACKGROUND: The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (I(Kr)), which is a crucial determinant of cardiac repolarization. The reduction of hERG current is commonly believed to cause Long QT Syndrome...

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Detalles Bibliográficos
Autores principales: Shi, Yuan-Qi, Fan, Pan, Zhang, Guo-Cui, Zhang, Yu-Hao, Li, Ming-Zhu, Wang, Fang, Li, Bao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327797/
https://www.ncbi.nlm.nih.gov/pubmed/31657676
http://dx.doi.org/10.2174/1381612825666191026170033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327797/
https://www.ncbi.nlm.nih.gov/pubmed/31657676
http://dx.doi.org/10.2174/1381612825666191026170033

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