2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their bioavailability, safety, and stability in vivo. However, chemical modifications variably impact target silencing for different siRNA sequences, ma...

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Detalles Bibliográficos
Autores principales: Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327867/
https://www.ncbi.nlm.nih.gov/pubmed/32610253
http://dx.doi.org/10.1016/j.omtn.2020.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327867/
https://www.ncbi.nlm.nih.gov/pubmed/32610253
http://dx.doi.org/10.1016/j.omtn.2020.05.010

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