Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition

Mesenchymal stem cells (MSCs) are multilineage adult stem cells with considerable potential for cell‐based regenerative therapies. In vitro expansion changes their epigenetic and cellular properties, with a poorly understood impact on DNA damage response (DDR) and genome stability. We report here re...

Descripción completa

Detalles Bibliográficos
Autores principales: Bao, Xuanwen, Wang, Jing, Zhou, Guangming, Aszodi, Attila, Schönitzer, Veronika, Scherthan, Harry, Atkinson, Michael J., Rosemann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915/
https://www.ncbi.nlm.nih.gov/pubmed/32333827
http://dx.doi.org/10.1002/2211-5463.12867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915/
https://www.ncbi.nlm.nih.gov/pubmed/32333827
http://dx.doi.org/10.1002/2211-5463.12867

Ejemplares similares