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Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition
Mesenchymal stem cells (MSCs) are multilineage adult stem cells with considerable potential for cell‐based regenerative therapies. In vitro expansion changes their epigenetic and cellular properties, with a poorly understood impact on DNA damage response (DDR) and genome stability. We report here re...
Autores principales: | Bao, Xuanwen, Wang, Jing, Zhou, Guangming, Aszodi, Attila, Schönitzer, Veronika, Scherthan, Harry, Atkinson, Michael J., Rosemann, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915/ https://www.ncbi.nlm.nih.gov/pubmed/32333827 http://dx.doi.org/10.1002/2211-5463.12867 |
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