SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular senescence; however, its effects h...

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Detalles Bibliográficos
Autores principales: Sung, Jin Young, Kim, Seul Gi, Cho, Du Hyong, Kim, Jae‐Ryong, Choi, Hyoung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920/
https://www.ncbi.nlm.nih.gov/pubmed/32421926
http://dx.doi.org/10.1002/2211-5463.12895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920/
https://www.ncbi.nlm.nih.gov/pubmed/32421926
http://dx.doi.org/10.1002/2211-5463.12895

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