Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK pathway. Here we used varying doses of two agents, Mito-Paraquat and Mito-M...

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Detalles Bibliográficos
Autores principales: Chowdhury, Anindya Roy, Zielonka, Jacek, Kalyanaraman, Balaraman, Hartley, Richard C., Murphy, Michael P., Avadhani, Narayan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327929/
https://www.ncbi.nlm.nih.gov/pubmed/32604037
http://dx.doi.org/10.1016/j.redox.2020.101606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327929/
https://www.ncbi.nlm.nih.gov/pubmed/32604037
http://dx.doi.org/10.1016/j.redox.2020.101606

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