The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases

To reach the central nervous system (CNS), drugs must cross the brain-blood barrier and have appropriate pharmacokinetic/dynamic properties. However, in early drug discovery steps, the selection of lead compounds, for example, those targeting G-protein-coupled receptors (GPCRs), is made according to...

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Detalles Bibliográficos
Autores principales: Franco, Rafael, Castelló, Josema, Canela, Enric I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Neuropharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327946/
https://www.ncbi.nlm.nih.gov/pubmed/31573886
http://dx.doi.org/10.2174/1570159X17666191001144309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327946/
https://www.ncbi.nlm.nih.gov/pubmed/31573886
http://dx.doi.org/10.2174/1570159X17666191001144309

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