AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activity

Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process strictly dependent on the APC/C coactivator FZR1....

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Detalles Bibliográficos
Autores principales: Abdelbaki, Ahmed, Akman, H. Begum, Poteau, Marion, Grant, Rhys, Gavet, Olivier, Guarguaglini, Giulia, Lindon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328152/
https://www.ncbi.nlm.nih.gov/pubmed/32393600
http://dx.doi.org/10.1242/jcs.243071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328152/
https://www.ncbi.nlm.nih.gov/pubmed/32393600
http://dx.doi.org/10.1242/jcs.243071

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