OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

Optineurin (OPTN) is a multifunctional protein involved in autophagy and secretion, as well as nuclear factor κB (NF-κB) and IRF3 signalling, and OPTN mutations are associated with several human diseases. Here, we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear regi...

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Detalles Bibliográficos
Autores principales: O'Loughlin, Thomas, Kruppa, Antonina J., Ribeiro, Andre L. R., Edgar, James R., Ghannam, Abdulaziz, Smith, Andrew M., Buss, Folma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328155/
https://www.ncbi.nlm.nih.gov/pubmed/32376785
http://dx.doi.org/10.1242/jcs.239822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328155/
https://www.ncbi.nlm.nih.gov/pubmed/32376785
http://dx.doi.org/10.1242/jcs.239822

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