Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

BACKGROUND: MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important role in ALS; however, the pathogenic mechanisms of deregulated miRNAs are still u...

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Detalles Bibliográficos
Autores principales: Kim, Ki Yoon, Kim, Yu Ri, Choi, Kyung Won, Lee, Mijung, Lee, Somyung, Im, Wooseok, Shin, Je-Young, Kim, Jin Young, Hong, Yoon Ho, Kim, Manho, Kim, Jong-Il, Sung, Jung-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328278/
https://www.ncbi.nlm.nih.gov/pubmed/32605607
http://dx.doi.org/10.1186/s40035-020-00203-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328278/
https://www.ncbi.nlm.nih.gov/pubmed/32605607
http://dx.doi.org/10.1186/s40035-020-00203-4

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