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Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients
BACKGROUND: MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important role in ALS; however, the pathogenic mechanisms of deregulated miRNAs are still u...
Autores principales: | Kim, Ki Yoon, Kim, Yu Ri, Choi, Kyung Won, Lee, Mijung, Lee, Somyung, Im, Wooseok, Shin, Je-Young, Kim, Jin Young, Hong, Yoon Ho, Kim, Manho, Kim, Jong-Il, Sung, Jung-Joon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328278/ https://www.ncbi.nlm.nih.gov/pubmed/32605607 http://dx.doi.org/10.1186/s40035-020-00203-4 |
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