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Competition between maturation and degradation drives human snRNA 3′ end quality control

Polymerases and exonucleases act on 3′ ends of nascent RNAs to promote their maturation or degradation but how the balance between these activities is controlled to dictate the fates of cellular RNAs remains poorly understood. Here, we identify a central role for the human DEDD deadenylase TOE1 in d...

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Detalles Bibliográficos
Autores principales: Lardelli, Rea M., Lykke-Andersen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328512/
https://www.ncbi.nlm.nih.gov/pubmed/32499401
http://dx.doi.org/10.1101/gad.336891.120