Agonist-specific desensitization of PGE(2)-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts

Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3′,5′-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E(2) (PGE(2)) can stimul...

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Detalles Bibliográficos
Autores principales: Nunez, Francisco J., Schulte, Nancy A., Fogel, David M., Michalski, Joel, Rennard, Stephen I., Penn, Raymond B., Toews, Myron L., Ostrom, Rennolds S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328663/
https://www.ncbi.nlm.nih.gov/pubmed/31884570
http://dx.doi.org/10.1007/s00210-019-01800-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328663/
https://www.ncbi.nlm.nih.gov/pubmed/31884570
http://dx.doi.org/10.1007/s00210-019-01800-5

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