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Agonist-specific desensitization of PGE(2)-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts
Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3′,5′-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E(2) (PGE(2)) can stimul...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328663/ https://www.ncbi.nlm.nih.gov/pubmed/31884570 http://dx.doi.org/10.1007/s00210-019-01800-5 |