Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial

INTRODUCTION: Targeted biologic therapies demonstrate similar efficacies in rheumatoid arthritis despite distinct mechanisms of action. They also exhibit a ceiling effect, with 10% to 20% of patients achieving remission in clinical trials. None of these therapies target synovial fibroblasts, which d...

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Detalles Bibliográficos
Autores principales: Siebert, Stefan, Pratt, Arthur G., Stocken, Deborah D., Morton, Miranda, Cranston, Amy, Cole, Michael, Frame, Sheelagh, Buckley, Christopher D., Ng, Wan-Fai, Filer, Andrew, McInnes, Iain B., Isaacs, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
6900
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328978/
https://www.ncbi.nlm.nih.gov/pubmed/32590730
http://dx.doi.org/10.1097/MD.0000000000020458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328978/
https://www.ncbi.nlm.nih.gov/pubmed/32590730
http://dx.doi.org/10.1097/MD.0000000000020458

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