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Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial

INTRODUCTION: Targeted biologic therapies demonstrate similar efficacies in rheumatoid arthritis despite distinct mechanisms of action. They also exhibit a ceiling effect, with 10% to 20% of patients achieving remission in clinical trials. None of these therapies target synovial fibroblasts, which d...

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Detalles Bibliográficos
Autores principales:	Siebert, Stefan, Pratt, Arthur G., Stocken, Deborah D., Morton, Miranda, Cranston, Amy, Cole, Michael, Frame, Sheelagh, Buckley, Christopher D., Ng, Wan-Fai, Filer, Andrew, McInnes, Iain B., Isaacs, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2020
Materias:	6900
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328978/ https://www.ncbi.nlm.nih.gov/pubmed/32590730 http://dx.doi.org/10.1097/MD.0000000000020458

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