Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology

A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα potently neutralizes HCMV in tissue culture, and its poten...

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Detalles Bibliográficos
Autores principales: Park, Jihye, Gill, Kevin Sean, Aghajani, Ali Asghar, Heredia, Jeremiah Dallas, Choi, Hannah, Oberstein, Adam, Procko, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329128/
https://www.ncbi.nlm.nih.gov/pubmed/32559251
http://dx.doi.org/10.1371/journal.ppat.1008647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329128/
https://www.ncbi.nlm.nih.gov/pubmed/32559251
http://dx.doi.org/10.1371/journal.ppat.1008647

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