A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5

Dysregulation of the Ras oncogene in development causes developmental disorders, “Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras mono- and di-ubiquitination. We report here that...

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Detalles Bibliográficos
Autores principales: Washington, Chalita, Chernet, Rachel, Gokhale, Rewatee H., Martino-Cortez, Yesenia, Liu, Hsiu-Yu, Rosenberg, Ashley M., Shahar, Sivan, Pfleger, Cathie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329146/
https://www.ncbi.nlm.nih.gov/pubmed/32559233
http://dx.doi.org/10.1371/journal.pgen.1008715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329146/
https://www.ncbi.nlm.nih.gov/pubmed/32559233
http://dx.doi.org/10.1371/journal.pgen.1008715

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