Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells

BACKGROUND: Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, l...

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Detalles Bibliográficos
Autores principales: Conroy, Lindsey R., Lorkiewicz, Pawel, He, Liqing, Yin, Xinmin, Zhang, Xiang, Rai, Shesh N., Clem, Brian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329430/
https://www.ncbi.nlm.nih.gov/pubmed/32624705
http://dx.doi.org/10.1186/s12935-020-01357-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329430/
https://www.ncbi.nlm.nih.gov/pubmed/32624705
http://dx.doi.org/10.1186/s12935-020-01357-x

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