Cargando…

Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells

BACKGROUND: Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conroy, Lindsey R., Lorkiewicz, Pawel, He, Liqing, Yin, Xinmin, Zhang, Xiang, Rai, Shesh N., Clem, Brian F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329430/ https://www.ncbi.nlm.nih.gov/pubmed/32624705 http://dx.doi.org/10.1186/s12935-020-01357-x

Ejemplares similares

Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo
por: Conroy, Lindsey R., et al.
Publicado: (2020)

RB in glutamine metabolism
por: Clem, Brian
Publicado: (2014)

Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
por: Tardito, Saverio, et al.
Publicado: (2015)

The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells
por: Ye, Ling-Yun, et al.
Publicado: (2017)

Novel sequential treatment with palbociclib enhances the effect of cisplatin in RB-proficient triple-negative breast cancer
por: Huang, Yajing, et al.
Publicado: (2020)

Serum glutamine, set-shifting ability and anorexia nervosa
por: Nakazato, Michiko, et al.
Publicado: (2010)

Effect of DNA methylation inhibitor on RASSF1A genes expression in non-small cell lung cancer cell line A549 and A549DDP
por: Mengxi, Duan, et al.
Publicado: (2013)

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
por: Cox, Andrew G., et al.
Publicado: (2016)

Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin
por: Litwiniec, Anna, et al.
Publicado: (2013)

Antagonistic effects of MYC and hypoxia in channeling glucose and glutamine into de novo nucleotide biosynthesis
por: Fan, Teresa, et al.
Publicado: (2014)

Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation
por: Lorkiewicz, Pawel K., et al.
Publicado: (2019)

NMR studies of the relationship between the changes of membrane lipids and the cisplatin-resistance of A549/DDP cells
por: Huang, Zhenhua, et al.
Publicado: (2003)

MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin
por: Li, Weili, et al.
Publicado: (2016)

Troglitazone suppresses tumor cell growth and glutamine metabolism through a PPAR-independent mechanism
por: Reynolds, Miriam, et al.
Publicado: (2014)

Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells
por: Zhu, Huijun, et al.
Publicado: (2005)

Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment
por: Gao, Yanyun, et al.
Publicado: (2019)

Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart
por: Yan, Keqiang, et al.
Publicado: (2022)

Identification of functional single nucleotide polymorphisms in the branchpoint site
por: Chiang, Hung-Lun, et al.
Publicado: (2017)

A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus
por: Zhu, Ying, et al.
Publicado: (2017)

Control of Glutamine Metabolism By the Tumor Suppressor Rb
por: Reynolds, Miriam R., et al.
Publicado: (2013)

Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells
por: Klimaszewska-Wisniewska, Anna, et al.
Publicado: (2016)

Ranking non-synonymous single nucleotide polymorphisms based on disease concepts
por: Shihab, Hashem A, et al.
Publicado: (2014)

The archaeal transamidosome for RNA-dependent glutamine biosynthesis
por: Rampias, Theodoros, et al.
Publicado: (2010)

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate
por: Duan, Chenxin, et al.
Publicado: (2021)

Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer
por: Chang, Wei-Chiao, et al.
Publicado: (2014)

Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti
por: Debrah, Linda Batsa, et al.
Publicado: (2017)

Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis
por: Wen, Jing, et al.
Publicado: (2018)

The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
por: Park, Danielle, et al.
Publicado: (2012)

Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma
por: Ye, Bo, et al.
Publicado: (2014)

Identification of long non-coding RNA using single nucleotide epimutation analysis: a novel gene discovery approach
por: Kerachian, Mohammad Amin, et al.
Publicado: (2022)

Predicting the combined effect of multiple genetic variants
por: Liu, Mingming, et al.
Publicado: (2015)

NONO promotes hepatocellular carcinoma progression by enhancing fatty acids biosynthesis through interacting with ACLY mRNA
por: Ding, Hongda, et al.
Publicado: (2020)

Single nucleotide polymorphisms of CD20 gene and their relationship with clinical efficacy of R-CHOP in patients with diffuse large B cell lymphoma
por: Ding, Huirong, et al.
Publicado: (2013)

Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse™ Probe System in challenging sequence environment
por: Belousov, Yevgeniy S, et al.
Publicado: (2004)

Single-nucleotide polymorphism rs17548629 in RIPK1 gene may be associated with lung cancer in a young and middle-aged Han Chinese population
por: Yang, Shimin, et al.
Publicado: (2020)

Association of relapse-linked ARID5B single nucleotide polymorphisms with drug resistance in B-cell precursor acute lymphoblastic leukemia cell lines
por: Tamai, Minori, et al.
Publicado: (2020)

Construction of a single nucleotide variant score-related gene-based prognostic model in hepatocellular carcinoma: analysis of multi-independent databases and validation in vitro
por: Xu, Yu-Jie, et al.
Publicado: (2021)

Combination of palbociclib and radiotherapy for glioblastoma
por: Whittaker, Shane, et al.
Publicado: (2017)

Palbociclib-Induced Liver Failure
por: Atallah, Rami, et al.
Publicado: (2020)

EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP
por: Li, Jiao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h19nnegch6q612jo4ei70vm75p