Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits. Fyn kinase physically associates with Tau and regulates subcellular distribution. Here, we assessed whether pharma...

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Detalles Bibliográficos
Autores principales: Tang, Si Jie, Fesharaki-Zadeh, Arman, Takahashi, Hideyuki, Nies, Sarah Helena, Smith, Levi M., Luo, Anin, Chyung, Annabel, Chiasseu, Marius, Strittmatter, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329553/
https://www.ncbi.nlm.nih.gov/pubmed/32611392
http://dx.doi.org/10.1186/s40478-020-00976-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329553/
https://www.ncbi.nlm.nih.gov/pubmed/32611392
http://dx.doi.org/10.1186/s40478-020-00976-9

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